Many prostate cancers relapse due to the generation of chemoresistance rendering first-line treatment drugs like paclitaxel (PTX) ineffective.The present study aims to determine the role of miRNAs and Hedgehog (Hh) pathway in chemoresistant prostate cancer and to evaluate the combination therapy using Hh inhibitor cyclopamine (CYA).Studies were con
Abstract Background Those attempting to implement changes in health care settings often find that intervention efforts do not progress as expected.Unexpected outcomes are often attributed to variation and/or error in implementation processes.We argue that some unanticipated Lifestyle variation in intervention outcomes arises because unexpected conv
Mycotoxins in solid foods and feeds jeopardize the public health of humans and animals and cause food security issues.The inefficacy of most preventive measures to control the production of fungi in foods and feeds during the pre-harvest and post-harvest stages incited interest in the mitigation of these mycotoxins that can be conducted by the appl
The differentiation of post-meiotic spermatids in animals is characterized by a unique reorganization of their nuclear architecture and chromatin composition.In many species, the formation of sperm nuclei involves the massive replacement of nucleosomes with protamines, followed by a phase of extreme nuclear compaction.At fertilization, the reconsti